Deadpool follows the story of Wade Wilson, a former Special Forces operative turned mercenary, who is diagnosed with terminal cancer. In a desperate attempt to find a cure, Wade undergoes an experimental treatment that not only fails to cure his cancer but also leaves him disfigured and with accelerated healing powers. After the procedure, Wade adopts the alter ego of Deadpool, a wisecracking anti-hero with a penchant for breaking the fourth wall. He embarks on a quest for revenge against Ajax, the man responsible for his transformation, and to win back his girlfriend, Vanessa.

The film opens with Deadpool in a taxi, preparing for a confrontation with Ajax. Through a series of flashbacks, we learn about Wade's past, his relationship with Vanessa, and the events leading up to his transformation into Deadpool. After the failed treatment, Wade's appearance is grotesque, and he struggles with his new identity. He dons a red and black suit, which becomes his signature look, and sets out to hunt down Ajax, who has kidnapped Vanessa.

As Deadpool navigates the criminal underworld, he encounters various henchmen and mercenaries, showcasing his unique combat skills and dark humor. His journey is filled with action-packed sequences, including a memorable fight on a freeway where he takes on multiple armed thugs while delivering witty one-liners. Along the way, he also forms an unlikely alliance with Colossus, a member of the X-Men, and Negasonic Teenage Warhead, a young mutant with explosive powers.

The climax of the film occurs in a scrapyard where Deadpool confronts Ajax and his henchmen. In a chaotic battle, Deadpool showcases his resilience and combat prowess, ultimately defeating Ajax and rescuing Vanessa. The film concludes with Deadpool and Vanessa rekindling their romance, as he learns to embrace his new identity and the chaos that comes with it. The post-credits scene teases a potential sequel, leaving audiences eager for more of Deadpool's irreverent adventures.

• In a comedic taxi ride, Deadpool shares quirky love advice with cab driver Dopinder, who is smitten with a woman named Gita. As they discuss the ups and downs of romance, Deadpool humorously warns Dopinder about the consequences of love, likening it to a pleasant scent. The scene briefly shifts to Deadpool's chaotic lair, where a blind woman comically trips over a duffel bag of ammunition, underscoring the absurdity of Deadpool's life.
• In this comedic scene, Deadpool and his taxi driver Dopinder share a playful exchange in a cab on a busy freeway. As Deadpool prepares for his mission by loading his guns, Dopinder offers to turn back but is met with Deadpool's humorous refusal to pay the fare, opting instead for a high five. After a light-hearted farewell, Deadpool exits the cab, wishing Dopinder a Merry Christmas, while Dopinder responds with a quirky Tuesday greeting. The scene transitions to 'The Raft' prison, hinting at a darker turn in the narrative.
• In a chaotic freeway overpass scene, Deadpool dramatically drops into an Escalade and engages in a humorous yet brutal fight with four armed men. He introduces himself with witty banter, employs creative combat tactics, and uses the car's features for comedic effect. The action escalates as he ties one thug to the seat belt and kicks him out, leading to a spectacular crash that results in absurd injuries among the attackers. The scene concludes with Deadpool breaking the fourth wall, humorously questioning if he left the stove on before the chaos resumes.
• In a chaotic scene on a freeway overpass, Deadpool humorously emerges from an overturned S.U.V. surrounded by armed thugs. Engaging in witty banter about his red suit, he leaps into action as the thugs open fire. Showcasing his acrobatic skills and comedic timing, Deadpool counts down his bullets while taking down several thugs, despite suffering a minor injury. The action culminates in a dramatic showdown where he uses his katanas to defeat the last thug. The scene blends dark humor with intense violence, ending with Deadpool expressing frustration over not finding his target.
• In a townhouse foyer six years ago, Gavin Merchant argues with pizza delivery guy Jeremy when Wade Wilson, armed and menacing, unexpectedly enters. Wade demands the pizza, takes Merchant's wallet, and threatens both men while searching for Meghan Orlovsky. He uses dark humor to intimidate Jeremy, warning him to stay away from Meghan, all while casually eating pizza. The scene blends tension with absurdity, ending with Wade leaving Jeremy unharmed but Merchant in fear.
• At a lively skate park at night, Wade, a skate punk, interacts with a group of girls singing to Salt-N-Pepa's 'Shoop.' After throwing down a Polaroid of a terrified Jeremy, Meghan, an emo girl, picks it up and admires Wade, calling him her hero. Despite the girls' playful requests for him to take revenge on their step-dad and vice principal, Wade declines, reflecting on the weight of the term 'hero' as he walks away, caught between camaraderie and introspection.
• In the gritty atmosphere of Sister Margaret's bar, Wade Wilson navigates a night filled with unsavory characters. He engages in humorous banter with Weasel, the bartender, while playfully pranking Buck by sending him a drink from the intimidating Boothe, who initially threatens another patron. The scene blends dark comedy with tension, showcasing Wade's lightheartedness as he reflects on his violent past. Ultimately, Wade's antics diffuse the bar's chaos, leaving him and Weasel sharing a conspiratorial smile.
• In a lively bar setting, Wade humorously watches a fight on TV while a real brawl unfolds behind him. He discovers his friend Weasel has bet on his death, feeling betrayed. Amidst the chaos, Wade flirts with Vanessa, leading to witty exchanges about their troubled pasts. The scene escalates when Wade offers Vanessa money for her services, which she playfully accepts, culminating in a lighthearted yet tense atmosphere.
• Wade and Vanessa enjoy a playful night at the arcade, where Wade's enthusiasm for skeeball shines through as he humorously prioritizes the game over romance. Their banter reveals a desire to connect beyond superficial appearances, highlighted by a young boy's comment on Vanessa. Wade impressively scores high but faces disappointment at the prize counter due to insufficient tickets. Vanessa lightens the mood by contributing her tickets for a low-value prize, leading to a shared moment of laughter. The scene concludes with the couple leaving the arcade affectionately, hinting at a deeper bond.
• This scene is a playful montage of Wade and Vanessa's sexual escapades, each tied to different holidays. It begins with a passionate Valentine's Day moment, followed by humorous interactions during Chinese New Year and International Women's Day. The montage showcases their irreverent relationship through various holidays, culminating in a chaotic Thanksgiving encounter on the kitchen table, filled with spilled food and laughter.
• In Wade's apartment, he and Vanessa don hilariously awful Christmas sweaters while playfully discussing a holiday visit. Vanessa surprises Wade with a limited edition Voltron ring, showcasing her dedication. They share a heartfelt moment, almost proposing to each other, culminating in Wade presenting a candy ring as a symbol of his love. Vanessa joyfully accepts, leading to a celebration captured in a Polaroid photo. The scene ends with Wade humorously passing out on the floor, highlighting their light-hearted and romantic connection.
• In a doctor's office, Wade and Vanessa receive the heartbreaking news of Wade's late-stage cancer diagnosis from a solemn oncologist. While Vanessa immediately seeks potential treatments, recalling an experimental drug that helped her uncle, Wade struggles to process the news, memorizing Vanessa's face in a moment of despair. The scene is punctuated by Deadpool's voiceover, which injects dark humor into the grim situation, contrasting Wade's emotional turmoil with his coping mechanism. The scene ends with the oncologist encouraging Wade to take time to absorb the diagnosis, setting the stage for a shift to a more action-oriented narrative.
• In Wade's apartment, he grapples with his cancer diagnosis while packing for an uncertain future. As he reflects on his possessions, he discards a Deadpool action figure but cherishes a Wham! vinyl album. Vanessa confronts him about his decision to leave, expressing her frustration and determination to fight the illness together. Their heartfelt conversation culminates in a tender kiss, symbolizing their deep bond amidst the turmoil.
• In this emotionally charged scene, Wade grapples with the weight of Vanessa's cancer diagnosis. After a tender moment with her in bed, he leaves to seek help, revealing his vulnerability and desperation. At a bar, he confides in Weasel about his struggles and shows him a Polaroid of happier times with Vanessa. Weasel offers support and hands Wade a mysterious business card, hinting at a potential new path in his quest for a cure.
• In a dimly lit bar, Wade, a former special forces operative battling terminal cancer, encounters a mysterious recruiter who offers him a chance to cure his illness and gain superhuman abilities. Despite the gravity of his situation, Wade responds with dark humor and sarcasm, reflecting on his negative experiences with heroism. The solemn nods from bar patrons Beef and Boothe underscore the weight of Wade's predicament. Ultimately, Wade rejects the recruiter's proposal, asserting that their paths may cross again only if he reaches a breaking point.
• In a rundown clinic waiting room in Guadalajara, Wade and Vanessa grapple with their anxiety over his illness. They encounter an elderly couple sharing their cancer struggles, deepening Wade's despair. Frustrated by the sight of a mother counting cash for her sick son, Wade offers a crumpled dollar for the boy's lollipop, showcasing his empathy despite his own dire situation. The scene captures the emotional toll of illness, culminating in a poignant moment of shared sorrow between Wade and Vanessa as they look at the sick boy.
• In a grim operating room, Abe lies unaware of the gruesome reality as Dr. Delgado performs a mock surgery, presenting him with a bloody tumor made from chicken gizzards. Wade bursts in, discovering the truth and confronting Delgado. A violent struggle ensues, culminating in Wade killing Delgado in a fit of rage, leaving Vanessa horrified by the aftermath.
• Wade, on the brink of death, is brought into a dimly lit laboratory where he faces a brutal experimental procedure to activate his mutant genes. Clutching a recruiter’s card and a Voltron ring, he initially holds onto hope, but his confidence wanes as he witnesses the fear of other patients. Ajax, the menacing recruiter, explains the painful process while Angel Dust, a strong presence, physically restrains Wade. Despite the grim situation, Wade attempts to use humor to cope, leading to a punch from Angel Dust as the scene fades to black.
• In a harrowing montage set to John Denver's 'I Want to Live,' Wade endures brutal torture and experimentation in a dimly lit Workshop, overseen by Ajax and assisted by Angel Dust. Ajax explains that Wade must suffer extreme pain to activate his mutant genes, while Wade gasps and screams through various invasive procedures. The scene juxtaposes the upbeat music with graphic depictions of Wade's suffering, culminating in Ajax's ominous promise to continue the torment until Wade either mutates or dies.
• In a dimly lit workshop, Wade, strapped to a table, engages in light-hearted banter with Cunningham about their bucket lists. Their conversation is interrupted by Ajax and Angel Dust, who come to prepare for Wade's torture. Wade taunts Ajax by revealing his real name, Francis, and mocks his threats, which only irritates Ajax further. The scene blends dark humor with tension as Wade's defiance against Ajax's authority escalates, culminating in Ajax's frustrated glare at Wade.
• In a dimly lit workshop, Wade is trapped in a plexiglass capsule, subjected to a torturous device designed by Ajax and Angel Dust to manipulate his oxygen levels. As Ajax explains their cruel plan to turn him into a super-slave for auction, Wade maintains his sarcastic demeanor despite the escalating panic as his breathing becomes labored. The scene blends dark humor with tension, culminating in Wade gasping for air, highlighting his desperate struggle against his captors.
• In a dark workshop tent, Wade gasps for air in a punch-bowl, initially relieved by a doctor's news that his cancer cells have become productive. However, his moment of hope is shattered when Ajax reappears, locking him back in the punch-bowl and resuming his torment. Horrified by his monstrous reflection, Wade silently screams, overwhelmed by despair as his struggle for survival turns into a nightmare.
• In a rundown duplex, Deadpool, exhausted and without his mask or right hand, weakly knocks on the door with his head, struggling to enter his own home. Inside, Blind Al, an elderly blind woman, diligently assembles furniture with a box cutter, showcasing her resourcefulness. The scene highlights Deadpool's vulnerability and the absurdity of his situation, while contrasting it with Blind Al's determination, all set against the backdrop of their cluttered living space.
• In a comedic scene set in Deadpool's cluttered lair, Blind Al hilariously trips over a Roomba while trying to reach the front door, leading to a face-plant. Deadpool bursts in, slamming the door into her head, and they engage in witty banter about their chaotic living situation and his failed attempts to catch the villain Francis. As Blind Al struggles with assembling an IKEA shelving unit, Deadpool mocks her efforts and shares his frustrations through sarcastic humor. The scene culminates in a light-hearted moment as Deadpool farts while walking past Blind Al, who expresses her anger towards the person who sold them the faulty furniture.
• In a chaotic workshop engulfed in flames, Wade uses a matchstick to ignite oxygen, triggering an explosion that leads to a brutal confrontation with Ajax. Despite gaining the upper hand, Wade hesitates when Ajax taunts him about his appearance, allowing Ajax to impale him with rebar. As Wade struggles to save Cunningham from the wreckage, the scene culminates in the roof collapsing on them, leaving their fates uncertain.
• Wade awakens in a workshop, having miraculously healed from a severe wound but grappling with his horrifying appearance. As he attempts to confront Vanessa, he is paralyzed by anxiety and the judgment of others. The emotional distance between them is palpable, and just as he gathers the courage to approach her, he is abruptly struck by a bus, leaving his internal conflict unresolved.
• In a laundromat, Deadpool struggles to clean blood from his white suit and receives advice from Blind Al to switch to red. Inspired, he crafts a new red outfit, complete with a lucha libre mask, and infiltrates an underground fight scene. There, he brutally interrogates thugs to gather information about his nemesis, Francis Freeman, blending humor with violence. The scene culminates in Deadpool successfully extracting crucial intel, setting the stage for his next confrontation.
• In a brightly lit room filled with rice bags, Deadpool humorously reveals himself to a fleeing recruiter, swiftly dispatching two armed thugs in a violent yet comedic showdown. After eliminating the thugs, he corners the recruiter in an alley, brandishing a sword and demanding information about his boss, blending dark humor with menacing threats.
• In this comedic scene, Wade and Weasel humorously discuss Wade's appearance and potential superhero identities, leading to the birth of the name 'Deadpool.' They toast to Wade's new identity, which transitions into a lively montage of Wade transforming into Deadpool, showcasing his iconic mask and costume while reflecting on his relationship with Vanessa. The montage culminates in a festive atmosphere as Deadpool decorates his lair and prepares for a showdown with Ajax, triumphantly pinning Ajax's mug shot atop a Christmas tree.
• Deadpool hails a taxi driven by Dopinder, encountering a surprising passenger, Bernadette Peters, before humorously addressing the audience and launching into a rapid montage of his past escapades. The scene shifts to a warehouse where Ajax, recovering from injuries, plots with Angel Dust to eliminate Deadpool, showcasing their dark intentions and Ajax's confidence in their strategy.
• In this scene, Deadpool lounges on his futon, reflecting on his emotional struggles while under the influence of medication. Blind Al enters with Tylenol and tea, engaging in a humorous yet heartfelt conversation about Deadpool's insecurities regarding love and his appearance. Despite her encouragement to pursue his feelings for a woman he loves, Deadpool dismisses her advice. The mood shifts when Weasel calls with urgent news, prompting Deadpool and Weasel to head to a strip club in search of Vanessa, setting the stage for their next adventure.
• In this scene, Deadpool and Weasel arrive at the 'No. 5 Orange' strip club in search of Vanessa. Deadpool is momentarily distracted by a cocktail waitress, only to panic upon realizing it's Vanessa. Meanwhile, Vanessa is confronted by Ajax and Angel Dust in the alley, where she tries to defend herself but is overpowered. After hesitating, Deadpool decides to find her, only to discover her belongings scattered in the alley, signaling that trouble has ensued.
• In a tense scene, Ajax and Angel Dust hold Vanessa captive in an industrial elevator, plotting to use her as leverage against Deadpool. Meanwhile, Deadpool seeks help from Colossus at the X-Mansion, where he encounters the unimpressed Negasonic Teenage Warhead. The scene shifts to Deadpool's lair, where he and Weasel prepare an arsenal of weapons, filled with humorous banter, including Blind Al's unexpected antics with a rifle. The mix of dark humor and serious stakes sets the stage for an impending confrontation.
• In this comedic scene, Deadpool and Dopinder drive through the city in a cramped taxi, where Deadpool playfully mocks Dopinder's romantic woes with Gita. Colossus awkwardly sips a cappuccino in the back seat, while Negasonic Teenage Warhead humorously predicts Dopinder's lack of insurance. Dopinder reveals he has tied up his rival, Bandhu, in the trunk, prompting Deadpool to suggest a safer approach to win Gita's heart. The scene concludes with a high five between Deadpool and Dopinder, highlighting their camaraderie before they prepare for action.
• In a chaotic scrapyard, Deadpool and his team, Colossus and Negasonic Teenage Warhead, face off against armed mercenaries. As Angel Dust showcases her strength by overpowering Colossus, Negasonic retaliates with explosive force. Meanwhile, taxi driver Dopinder's distracted driving leads to a crash, adding to the chaos. The scene is filled with action, humor, and intense confrontations, culminating in a fierce battle that sets the stage for further conflict.
• In a chaotic scrapyard, Deadpool finds himself under heavy fire from mercenaries. Attempting to negotiate with humor by waving torn tightie-whities as a white flag, he is ignored and instead charges at them. Showcasing his agility and combat skills, he takes out several mercs using a boot knife and gunfire while maneuvering through the debris. The scene culminates with Deadpool drawing his katanas, ready to continue the fight.
• In a chaotic scrapyard, Colossus battles Angel Dust, showcasing strength and agility. Meanwhile, Deadpool engages in a frenetic fight against mercenaries, humorously confronting his old acquaintance Bob before facing off against Ajax and his armed crew. As the conflict escalates, Negasonic Teenage Warhead aids Deadpool by launching him into the air using a broken plane wing, setting the stage for more explosive action.
• On the chaotic flight deck, Deadpool, battered and bloodied, confronts Ajax, who threatens Vanessa's life while she gasps for air in a punch bowl. After dispatching an injured mercenary, Deadpool throws a katana to partially free Vanessa, escalating the tension between him and Ajax, who readies for a fight with two axes. The scene ends with a booming sound from below, leaving their confrontation unresolved.
• In a climactic battle on a collapsing flight deck, Deadpool faces off against Ajax in a brutal fight filled with humor and intensity. After injuring Ajax, Deadpool is severely hurt but is saved by Vanessa, who frees herself and stabs Ajax, allowing Deadpool to deliver a decisive blow. As the flight deck crumbles due to explosions from a nearby fight, Deadpool and Vanessa narrowly escape in a punchbowl, leading to a chaotic destruction scene. The moment ends with Vanessa humorously threatening Deadpool's life if they survive.
• In a dusty scrapyard, Deadpool battles Ajax, ultimately killing him despite Colossus's pleas for mercy. Vanessa emerges from the wreckage, confronting Deadpool about his absence, and they share a romantic moment, culminating in a kiss, while Negasonic Teenage Warhead provides humorous commentary. The scene blends dark humor, tension, and romance, ending with their passionate kiss set to 'Careless Whisper.'
• In a modern workshop, a lab technician prepares a sickly volunteer for an unsettling experiment, while Dr. Killebrew ominously assures him of a transformation. Meanwhile, Deadpool and Vanessa share an intimate moment in a scrapyard, reflecting on their relationship amidst the dark undertones of the experiment. The scene blends dark humor with romance, culminating in the credits rolling to 'Careless Whisper.'